A Solvent- and Metal-Free Synthesis of 3-Chacogenyl-indoles Employing DMSO/I-2 as an Eco-friendly Catalytic Oxidation System

作者:Azeredo Juliano B; Godoi Marcelo; Martins Guilherme M; Silveira Claudio C*; Braga Antonio L
来源:Journal of Organic Chemistry, 2014, 79(9): 4125-4130.
DOI:10.1021/jo5000779

摘要

Herein, we describe a solvent- and metal-free method for the synthesis of 3-chalcogenyl-indoles from indoles and diorganyl dichalcogenides using an equivalent amount of DMSO as an oxidant, under catalysis by molecular iodine. This mild and eco-friendly approach allowed the preparation of a wide range of 3-selenyl- and 3-sulfenyl-indoles in good to excellent yields.

  • 出版日期2014-5-2