Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes

作者：Wu, Changqiang; Li, Danyang; Yang, Li; Lin, Bingbing; Zhang, Houbing; Xu, Ye; Cheng, Zhuzhong; Xia, Chunchao; Gong, Qiyong; Song, Bin; Ai, Hua^*

来源：Journal of Materials Chemistry B, 2015, 3(8): 1470-1473.

DOI：10.1039/c4tb02036g

• NEPHROGENIC SYSTEMIC FIBROSIS
• RESONANCE-IMAGING PROBES
• CONTRAST AGENTS
• RESOLUTION

T-1 contrast agents based on Mn(II) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T-1 relaxivity (13.3 Mn mmol(-1) s(-1)) and better sensitivity than those of free Mn(II) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg(-1) BW).

• 出版日期2015
• 单位四川大学