Use of Selective Serotonin Reuptake Inhibitors and Risk of Hip Fracture in the Elderly: A Case-Control Study in Taiwan

作者：Hung Shih Chang; Lin Chih Hsueh; Hung Hung Chang; Lin Cheng Li; Lai Shih Wei

来源：Journal of the American Medical Directors Association, 2017, 18(4): 350-354.

DOI：10.1016/j.jamda.2016.12.003

• Adverse effect
• epidemiology
• fall

Background: This population based study investigated the relationship between use of selective serotonin reuptake inhibitors (SSRIs) and hip fractures in the elderly in Taiwan.
Methods: Analysis of a random sample of 1 million insurance enrollees' data identified 4,891 patients with newly diagnosed hip fractures and 4,891 controls without hip fracture between 2000 and 2011. Both cases and controls were >= 65 years of age and were matched by sex, age, comorbidities, and index year of hip fracture diagnosis. Patients were considered current SSRI users if their last SSRI tablet was taken <= 7 days before the hip fracture diagnosis. Late use of SSRIs was defined as taking the last SSRI tablet <= 8 days before the hip fracture diagnosis. Non-SSRI users comprised individuals who never had an SSRI prescription. Odds ratios (ORs) and 95% confidence intervals (CIs) for hip fracture associated with SSRI use was estimated by multivariate unconditional logistic regression.
Results: After adjustment for covariants, multivariate regression analysis showed that the adjusted OR of hip fracture was 2.17 for current SSRI users (95% CI: 1.60-2.93) compared with those who never used SSRIs. The adjusted OR was 1.11 for individuals with late use of SSRIs (95% CI: 0.96-1.28) and was not significant.
Conclusions: Current use of SSRIs was associated with a 2.17-fold increase in the odds of hip fracture in the elderly in Taiwan. Clinicians should consider the possibility of SSRI-associated hip fracture among old people currently taking SSRIs.

• 出版日期2017-4-1
• 单位中国医科大学