Association of interleukin-6-174G > C promoter polymorphism with risk of cervical cancer

作者：Gangwar Ruchika; Mittal Balraj; Mittal Rama Devi^*

来源：International Journal of Biological Markers, 2009, 24(1): 11-16.

DOI：10.5301/jbm.2009.5370

• Cervical cancer
• Cytokine
• Genetic susceptibility
• Interleukin-6
• Polymorphism

Background: The etiology of cervical cancer is associated with excessive inflammation-mediated tumorigenesis. Interleukin-6 (IL-6), a multifunctional cytokine, regulates inflammation and various physiological processes. We therefore aimed to evaluate the association of the IL-6 -174G>C polymorphism with predisposition to cervical cancer.
Materials and methods: The present case-control study comprised 160 histopathologically confirmed cases of cervical cancer and 200 healthy controls. Polymorphism for the IL-6 gene was genotyped by amplification refractory mutation system (ARMS) polymerase chain reaction (PCR).
Results: We observed a significant association of the IL-6 -174CC genotype with risk of cervical cancer (OR=3.16; p=0.014). An increased risk of developing stage I tumors was found in individuals with a heterozygous (GC) genotype (OR=3.63, p=0.003). In a case-only analysis, the risk was further increased in patients consuming tobacco products (OR=3.14; p=0.033).
Conclusion: The CC genotype in the IL-6 promoter region may confer a high risk of cervical cancer, which is further modulated in patients who are tobacco users. (Int J Biol Markers 2009; 24: 11-6)

• 出版日期2009-3
• 单位河北医科大学