Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration?

作者：Witte Maarten E^*; Geurts Jeroen J G; de Vries Helga E; van der Valk Paul; van Horssen Jack

来源：Mitochondrion, 2010, 10(5): 411-418.

DOI：10.1016/j.mito.2010.05.014

• Mitochondria
• Neurodegeneration
• Neuroinflammation
• Reactive oxygen species
• MS
• EAE

Dysfunctional mitochondria are thought to play a cardinal role in the pathogenesis of various neurological disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease and stroke. In addition, neuroinflammation is a common denominator of these diseases. Both mitochondria' dysfunction and neuroinflammatory processes lead to increased production of reactive oxygen species (ROS) which are detrimental to neurons. Therefore, neuroinflammation is increasingly recognized to contribute to processes underlying neurodegeneration. Here we describe the involvement of mitochondria' (dys)function in various neurological disorders and discuss the putative link between mitochondrial function and neuroinflammation.

• 出版日期2010-8