Age dependent course of EAE in Aire(-/-) mice

作者：Aharoni Rina; Aricha Revital; Eilam Raya; From Ido; Mizrahi Keren; Arnon Ruth; Souroujon Miriam C; Fuchs Sara^*

来源：Journal of Neuroimmunology, 2013, 262(1-2): 27-34.

DOI：10.1016/j.jneuroim.2013.06.001

• Autoimmune regulator (Aire)
• Regulatory T cells (Treg)
• Experimental autoimmune encephalomyelitis (EAE)
• Autoimmunity
• Susceptibility

This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6 month old mice. In contrast, 2 month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.

• 出版日期2013-9-15