Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling

作者：Todorovic Slobodan M^*; Jevtovic Todorovic Vesna

来源：Pflugers Archiv-European Journal of Physiology, 2013, 465(7): 921-927.

DOI：10.1007/s00424-012-1211-y

• T-type channels
• Calcium
• Low-voltage-activated
• Hyperalgesia
• Allodynia
• Diabetes
• Nerve injury

Pain is an important clinical problem and, in its chronic form, may be a disabling condition. Most currently available therapies are insufficient and/or accompanied by serious side effects. Recent studies have implicated the Ca(V)3.2 isoform of T-type Ca channels in nociceptive signaling. Ca(V)3.2 channels are located in the somas of dorsal root ganglion cells and in the central endings of these cells in the dorsal horn of the spinal cord. These channels can support the development and maintenance of both physiological (nociceptive) and pathological (neuropathic) pain. In this review, we summarize the most recent evidence linking the presynaptic Ca(V)3.2 channels to the etiology of neuropathic pain disorders. In particular, we focus on data linking plasticity of Ca(V)3.2 channels with neuropathic pain disorders associated with mechanical peripheral nerve injury and with diabetic peripheral neuropathy. We also discuss the development of potential pain therapies aimed at these channels.

• 出版日期2013-7