Ultrafast Localized Two-Dimensional Magnetic Resonance Correlated Spectroscopy via Spatially Encoded Technique

作者：Lin, Yanqin; Zhang, Qinta; Wei, Zhiliang; Cai, Shuhui; Zhong, Jianhui; Chen, Zhong^*

来源：Magnetic Resonance in Medicine, 2014, 71(3): 903-910.

DOI：10.1002/mrm.24731

• localized magnetic resonance spectroscopy
• 2D correlated spectroscopy
• ultrafast
• spatially encoded

PurposeTo speed up acquisition of localized two-dimensional (2D) correlated spectroscopy (LCOSY).
MethodsA new pulse sequence, dubbed as spatially encoded localized COSY (SLCOSY), based on spatially encoded technique, was developed for localized 2D correlated spectroscopy. It can be used to collect a full 2D spectrum in a single scan and thus on a subsecond timescale.
ResultsSLCOSY spectrum of a two-compartment phantom was obtained with a total acquisition time of 773 ms, with its volume localization confirmed. Localized 2D COSY spectrum of a proton magnetic resonance spectroscopy brain phantom within 12 s shows the ability of SLCOSY to detect the metabolites at physiological concentrations. All 10 constituent metabolites in this phantom are reliably detected. SLCOSY spectrum of a sample of pig brain tissue with the acquisition time of 32 s demonstrates the feasibility of SLCOSY for the detection of biological tissues. Twelve pairs of cross peaks are identified.
ConclusionThe new method proposed herein enables ultrafast collection of a full 2D COSY spectrum, and it can also be used for fast in vivo analysis of metabolites, when signal-to-noise ratio is not a limiting factor. Magn Reson Med 71:903-910, 2014.

• 出版日期2014-3
• 单位厦门大学