Appropriate parameters of the ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with C-11-acetate PET

作者：Kobayashi Masato^*; Mori Tetsuya; Kiyono Yasushi; Tsujikawa Tetsuya; Maruyama Rikiya; Higaki Yusuke; Shikano Naoto; Nishii Ryuichi; Kawai Keiichi; Kudo Takashi; Okazawa Hidehiko

来源：Nuclear Medicine Communications, 2012, 33(2): 130-138.

DOI：10.1097/MNM.0b013e32834e7f5c

• C-11-acetate PET
• cardiology
• myocardial blood flow
• myocardial oxygen consumption
• ordered-subset expectation maximization

Objective The purpose of this study was to evaluate the appropriate parameters of a filter and of subsets (S) and iterations (I) of the ordered-subset expectation maximization (OSEM) algorithm in C-11-acetate PET. %26lt;br%26gt;Methods A Hanning filter (HF) and a Gaussian filter (GF) were selected for filtered back-projection (FBP) and the OSEM algorithm, respectively. After evaluation of the optimal HF size, the GF size was optimized using healthy volunteers (HV). Myocardial blood flow (MBF) and oxygen consumption (k(mono)) values were calculated by combining 4S, 16S, or 28S with 21, 41, 61, or 81 of the OSEM (MBFOSEM and k(monoOSEM), respectively) in eight HV and eight coronary artery disease (CAD) patients. These MBFOSEM and k(monoOSEM) values were compared with those obtained using FBP (MBFFBP and k(monoFBP), respectively). %26lt;br%26gt;Results Optimal HF and GF (10.0GF) sizes for the FBP and OSEM algorithms, respectively, were 10.0 mm full-width resolution at half-maximum. MBFOSEM was changed by modifying the parameters of the OSEM algorithm. The best correlations were between MBFFBP and MBFOSEM, with 28S6I and 10.0GF for HV patients and 28S8I for CAD patients. However, the MBFOSEM with 28S8I was significantly different from MBFFBP at the global myocardium in HV. The k(monoOSEM) with 28S6I was not significantly different from k(monoFBP) in HV or CAD patients. %26lt;br%26gt;Conclusion Appropriate parameters are 28S6I with a 10.0GF on the MBFOSEM and k(monoOSEM) measurement using C-11-acetate. Diagnostic performance will improve using noiseless, artifact-reduction images, and accurate quantitative values that are provided by the OSEM algorithm with the appropriate parameters.

• 出版日期2012-2