Amphiphilic graft polymer with reduction breakable main chain prepared via click polymerization and grafting onto

作者：Zhang, Xiaojin; Dai, Yu^*

来源：Journal of Nanoparticle Research, 2018, 20(6): 147.

DOI：10.1007/s11051-018-4256-9

• Amphiphilic graft polymer
• Reduction-responsive
• Click polymerization
• Grafting onto
• Micelles
• Drug delivery applications

Amphiphilic graft polymer PSS-g-Pal/PEG with reduction breakable main chain was synthesized via click polymerization of dialkynyl (containing disulfide bond) and diazide (containing pendant diol) and one-pot grafting onto of hydrophobic palmitate (Pal) and hydrophilic methoxy poly(ethylene glycol) (PEG). PSS-g-Pal/PEG is able to form polymeric micelles by self-assembly in water via dialysis. Polymeric micelles are nano-sized spheres and the particle size is approximately 70 nm. Of note, polymeric micelles are reduction-responsive owing to the disulfide bonds in main chain of PSS-g-Pal/PEG. Therefore, polymeric micelles prepared from amphiphilic graft polymer PSS-g-Pal/PEG are able to fast release the drugs in the presence of the reducing agents such as DL-dithiothreitol (DTT).

• 出版日期2018-5-27
• 单位中国地质大学（北京）