A rule-based seizure prediction method for focal neocortical epilepsy

作者：Aarabi Ardalan; He Bin^*

来源：Clinical Neurophysiology, 2012, 123(6): 1111-1122.

DOI：10.1016/j.clinph.2012.01.014

• Focal epilepsy
• Intracranial EEG
• Nonlinear dynamics
• Seizure prediction

Objective: In the present study, we have developed a novel patient-specific rule-based seizure prediction system for focal neocortical epilepsy.
Methods: Five univariate measures including correlation dimension, correlation entropy, noise level, Lempel-Ziv complexity, and largest Lyapunov exponent as well as one bivariate measure, nonlinear interdependence, were extracted from non-overlapping 10-s segments of intracranial electroencephalogram (iEEG) data recorded using electrodes implanted deep in the brain and/or placed on the cortical surface. The spatio-temporal information was then integrated by using rules established based on patient-specific changes observed in the period prior to a seizure sample for each patient. The system was tested on 316 h of iEEG data containing 49 seizures recorded in 11 patients with medically intractable focal neocortical epilepsy.
Results: For seizure occurrence periods of 30 and 50 min our method showed an average sensitivity of 79.9% and 90.2% with an average false prediction rate of 0.17 and 0.11/h, respectively. In terms of sensitivity and false prediction rate, the system showed superiority to random and periodical predictors.
Conclusions: The nonlinear analysis of iEEG in the period prior to seizures revealed patient-specific spatio-temporal changes that were significantly different from those observed within baselines in the majority of the seizures analyzed in this study.
Significance: The present results suggest that the patient specific rule-based approach may become a potentially useful approach for predicting seizures prior to onset.

• 出版日期2012-6