Muscle atrophy in cachexia: can dietary protein tip the balance?

作者：den Kamp Celine M Op; Langen Ramon C; Haegens Astrid; Schols Annemie M^*

来源：Current Opinion in Clinical Nutrition and Metabolic Care, 2009, 12(6): 611-616.

DOI：10.1097/MCO.0b013e3283319399

• cachexia
• dietary amino acids
• dietary protein
• muscle atrophy

Purpose of review
To review the efficacy of dietary protein supplementation in attenuating muscle atrophy in cachexia.
Recent findings
Only very few recent randomized controlled trials have studied the effects of protein supplementation in clinical cachexia. It appears that supplementation of dietary protein (> 1.5 g/kg per day) alone or in combination with other anabolic stimuli such as exercise training maintains or even improves muscle mass, but results on muscle function are controversial and no clinical studies have yet directly linked alterations in cellular signaling or metabolic signatures of protein intake-induced muscle anabolism to muscle weight gain.
Summary
To elucidate the role of dietary protein supplementation in attenuating muscle atrophy in cachectic patients, randomized clinical trials are needed in adequately phenotyped patients using sensitive measures of muscle mass and function.

• 出版日期2009-11