Downregulation of COUP-TFII inhibits glioblastoma growth via targeting MPC1

作者：Xiao, Bing; Fan, Yanghua; Ye, Minhua; Lv, Shigang; Xu, Bin; Chai, Yi; Wu, Miaojin^*; Zhu, Xingen^*

来源：Oncology Letters, 2018, 15(6): 9697-9702.

DOI：10.3892/ol.2018.8601

• chicken ovalbumin upstream promoter transcription factor II
• mitochondrial pyruvate carrier 1
• glioblastoma
• proliferation

Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is a steroid receptor that is broadly expressed in many tissues throughout embryonic development. Previous studies indicated that COUP-TFII is dysregulated in multiple types of cancer and serves crucial roles in cancer development. The mitochondrial pyruvate carrier 1 (MPC1) is involved in transporting pyruvate for entry into the citric acid cycle, an important event in cancer progression. However, the roles of COUP-TFII and MPC1 in glioma remain unknown. In the present study, it was demonstrated that MPC1 is downregulated in glioblastoma. Furthermore, the inhibition of COUP-TFII was able to increase MPC1 expression and inhibit the growth of glioblastoma cells in vitro and in vivo. The findings from the present study demonstrated that downregulation of COUP-TFII inhibits glioblastoma growth via targeting MPC1. Therefore, COUP-TFII is a potential therapeutic target for glioma.

• 出版日期2018-6
• 单位南昌大学