Dietary habits and selenium, glutathione peroxidase and total antioxidant status in the serum of patients with relapsing-remitting multiple sclerosis

作者：Socha Katarzyna^*; Kochanowicz Jan; Karpinska Elzbieta; Soroczynska Jolanta; Jakoniuk Marta; Mariak Zenon; Borawska Maria H

来源：Nutrition Journal, 2014, 13(1): 62.

DOI：10.1186/1475-2891-13-62

• Multiple sclerosis
• Selenium
• Glutathione peroxidase activity
• Total antioxidant status
• Dietary habits
• Smoking cigarettes

Background: Dietary habits and adequate dietary intake of antioxidants in the diet may be one of the most important environmental factors for the prevention of Multiple Sclerosis (MS).
Objectives: The aim of this study was to estimate selenium (Se) concentration, glutathione peroxidase (GSH-Px) activity and total antioxidant status (TAS) in the serum of patients with MS and the influence of dietary habits on the status.
Methods: 101 patients with relapsing-remitting MS (aged 18-58 years), as well as control group of 63 healthy people (aged 19-65 years) were studied. Food-frequency questionnaires were implemented to collect the dietary data. Se concentration in the serum samples was determined by atomic absorption spectrometry. GSH-Px activity and TAS in examined serum was measured using the ready-made sets of tests by Randox Laboratories Ltd., UK.
Results: Serum Se concentration and GSH-Px activity in the serum of patients with MS (55.2 +/- 16.2 g/L, 6676.1 +/- 2386.4 U/L; respectively) were significantly decreased (p<0.01, p<0.05; respectively) compared with control group (79.2 +/- 20.6 mu g/L, 8029.9 +/- 2650.1 U/L; respectively). A significant correlation (r=0.39, p<0.01) was observed between Se concentration and GSH-Px activity in the serum of examined patients. TAS value in the serum of patients with MS (1.03 +/- 0.37 mmol/L) was also significantly lower (p<0.01) than in healthy volunteers (1.48 +/- 0.41 mmol/L). Frequent consumption of poultry, bakery products, pulses and fish seemed to increase serum Se concentration in the group of patients; whereas frequent consumption of butter, wholegrain bread, sweet beverages and sugar was found to accompany with lower values of Se in the serum. We have observed significant decrease TAS (p<0.05, p<0.01; respectively) in the serum of smokers and those patients who received immunomodulatory drugs (0.95 +/- 0.39 mmol/L, 0.92 +/- 0.34 mmol/L; respectively) compared with no-smoking patients and not taking immunomodulators (1.14 +/- 0.33 mmol/L, 1.31 +/- 0.31 mmol/L; respectively).
Conclusions: Serum Se concentration, GSH-Px activity and TAS value were significantly lower in patients with relapsing-remitting MS compared with healthy volunteers. Dietary habits have a significant influence on Se status. Smoking cigarettes and intake of immunomodulatory drugs therapy have a negative impact on TAS of examined patients.

• 出版日期2014-6-18