Antifungal and Antibacterial Activity of the Newly Synthesized 2-Xanthone Derivatives

作者：Marona Henryk^*; Szkaradek Natalia; Karczewska Elzbleta; Trojanowska Danuta; Budak Alicia; Bober Plotr; Przepiorka Waldemar; Cegla Marek; Szneler Edward

来源：Archiv der Pharmazie, 2009, 342(1): 9-18.

DOI：10.1002/ardp.200800089

• Antibacterial
• Antifungal
• Synthesis
• Xanthone

A series of 2-substituted xanthone derivatives 8-20 containing selected allyl, cinnamyl, morpholine, and imidazole moieties were synthesized and tested for their antifungal and antibacterial in-vitro properties. Of the newly synthesized derivatives, ten revealed antifungal activity especially against Trichophyton mentagrophytes (the biggest inhibition zones ranged 35 mm for 11 and 13). 2-(3-(Allylamino)propoxy)-9H-xanthen-9-one hydrochloride 9 inhibited growth of all of the examined fungal species. Significant efficacy against evaluated yeasts and dermatophytes was also observed for 6-chloro-2-methyl-9H-xanthen-9-one derivatives 11 - 13 containing encyclic amine moieties. Additionally, compounds 9, 11, and 12 hindered development of bacteria species but in a lesser degree. They were efficacious against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis.

• 出版日期2009-1