Association of Interleukin-10-1082 G/G Genotype with Lower Mortality of Acute Respiratory Distress Syndrome in a Chinese Population

作者：Jin, Xiaodong^*; Hu, Zhi; Kang, Yan; Liu, Chang; Zhou, Yongfang; Wu, Xiaodong; Liu, Jin; Zhong, Mingxing; Luo, Chuanxing; Deng, Lijing; Deng, Yiyun; Xie, Xiaoqi; Zhang, Zhongwei; Zhou, Yan; Liao, Xuelian

来源：Genetic Testing and Molecular Biomarkers, 2011, 15(4): 203-206.

DOI：10.1089/gtmb.2010.0180

• CYTOKINE GENE POLYMORPHISMS
• TUMOR-NECROSIS-FACTOR
• PROMOTER POLYMORPHISM
• IL-10
• SEVERITY
• PREDICT

We investigate whether interleukin-10 (IL-10)-1082 G/G genotype is associated with the mortality rate of acute respiratory distress syndrome (ARDS) in a hospital-based case-control study in China conducted on 314 patients with ARDS and 210 controls admitted to an intensive care unit for sepsis, trauma, aspiration, or massive transfusions. IL-10-1082 promoter polymorphisms were analyzed with polymerase chain reaction amplification followed by restriction fragment length polymorphism. Mortality was recorded if it occurred within 30 days from admission. The -1082G/G genotype was associated with lower frequency of ARDS (odds ratios = 0.51; 95% confidence intervals: 0.34-0.76; p = 0.001), and in patients with ARDS, it was associated with lower mortality within 30 days (odds ratios = 0.44; 95% confidence intervals: 0.25-0.76; p = 0.003) than in controls. We conclude that IL-10-1082 G/G genotype is associated with a decreased rate development of ARDS and mortality in this Chinese population.

• 出版日期2011-4
• 单位四川大学