科研之友
微信
新浪微博
Facebook
分享链接
摘要
We report on the active template synthesis of a [2]rotaxane through a Goldberg, copper-catalyzed C-N bend forming reaction. A C-2-symmetric cyclohexyldiamine macrocycle directs the assembly of the rotaxane, which can subsequently serve as a ligand for enantioselective nickel-catalyzed :conjugate addition reactions. Rotaxanes are a previously unexplored ligand: architecture for asymmetric. catalysis. We find that the rotaxane gives improved enantioselectivity compared to a noninterlocked ligand, at the expense of longer reaction times.
- 出版日期2015-6-24
