An improved synthesis and some reactions of diethyl 4-oxo-4H-pyran-2,5-dicarboxylate

作者：Obydennov Dmitrii L^*; Roeschenthaler Gerd Volker; Sosnovskikh Vyacheslav Ya

来源：Tetrahedron Letters, 2013, 54(48): 6545-6548.

DOI：10.1016/j.tetlet.2013.09.100

• Claisen condensation
• Ethyl 2-(dimethylamino)methylene-3-oxobutanoate
• Diethyl oxalate
• 4-Oxo-4H-pyran-2,5-dicarboxylic acid
• 4-Oxo-1-phenyl-1,4-dihydropyridine-2,5-dicarboxylic acid

The reaction of ethyl 2-(dimethylamino)methylene-3-oxobutanoate with diethyl oxalate in the presence of sodium hydride in THF gave diethyl 4-oxo-4H-pyran-2,5-dicarboxylate, from which 4-oxo-4H-pyran-2,5-dicarboxylic and 4-oxo-1-phenyl-1,4-dihydropyridine-2,5-dicarboxylic acids and their derivatives were obtained in good yields.

• 出版日期2013-11-27