科研之友
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摘要
Objective: Various neuroimaging studies reported that transient ischemic attack (TIA) was associated with brain morphology changes, whereas the intrinsic brain activity changes in TIA patients remain unknown. The purpose of the study was to investigate alterations of spontaneous brain activity in TIA patients using the amplitude of low-frequency fluctuation (ALFF) method and its correlation with clinical features. Methods: A total of 25 patients with TIA (15 males and 10 females) and 25 healthy controls (HCs) (15 males and 5 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was used to assess spontaneous brain activities. Patients with TIA were distinguished from HCs by receiver operating characteristic (ROC) curve. The relationships between the mean ALFF signal values in many brain regions and clinical features in TIA patients were calculated by Pearson correlation analysis. Results: TIA patients had significantly lower ALFF values in the left cerebellum posterior lobe and right precentral/postcentral gyrus relative to the HCs. In contrast, the higher ALFF values in TIA patients were observed in the right prefrontal gyrus. However, no relationships were found between the mean ALFF signal values of the different areas and clinical manifestations in TIA patients. Conclusion: Our results demonstrated that TIA patients showed abnormal intrinsic brain activities in many brain regions related to motor control and cognition function, which might offer some useful information to explore neural mechanisms of TIA patients.
