An efficient regioselective copper catalyzed multi-component synthesis of 1,3-disubstituted pyrazoles

作者：Raghunadh Akula^*; Meruva Suresh Babu; Mekala Ramamohan; Rao K Raghavendra; Krishna Thalishetti; Chary R Gangadhara; Rao L Vaikunta; Kumar U K Syam

来源：Tetrahedron Letters, 2014, 55(18): 2986-2990.

DOI：10.1016/j.tetlet.2014.03.125

• Pyrazoles
• Multicomponent reaction
• Michael addition
• Cu catalyst and Ullmann cross-coupling reaction

An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceeds via a sequential series of reactions such as Michael addition, heterocyclization, dehydration, and Ullmann cross-coupling.

• 出版日期2014-4-30