Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress

作者：Takamiya Rina^*; Fukunaga Koichi; Arita Makoto; Miyata Jun; Seki Hiroyuki; Minematsu Naoto; Suematsu Makoto; Asano Koichiro

来源：FEBS Open Bio, 2012, 2(1): 328-333.

DOI：10.1016/j.fob.2012.10.001

• Cigarette smoke
• Resolvin E1
• Macrophage
• Reactive
• oxygen species

Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS-induced oxidative stress.

• 出版日期2012