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摘要
Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused alpha-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight alpha-carbolines was prepared by using this robust methodology for biological evaluation.
- 出版日期2012-6-6
