Potassium phosphate-ionic liquid mediated selective mono-Michael addition

作者：Sawant Anand D; Jagadale Suryabala D; Desai Uday V; Salunkhe Manikrao M^*

来源：New Journal of Chemistry, 2015, 39(9): 6726-6729.

DOI：10.1039/c5nj01225b

A simple and efficient process for an exclusive mono-Michael addition of active methylene compounds to conjugated esters, nitriles and ketones is developed. An ionic liquid-mediated reaction is carried out at room temperature. A reaction carried out at 60 degrees C resulted in a double-addition product. A mechanism is proposed and supported by P-31 and DOSY NMR analysis of the used ionic liquid.

• 出版日期2015