A novel recognition mechanism based on aldehyde group oxidized into carboxyl group by hypochlorite for the materials of fluorescent probes

作者：Xiong, Kangming; Huo, Fangjun; Zhang, Yongbin; Wen, Ying; Chao, Jianbin; Yin, Caixia^*

来源：Sensors and Actuators B: Chemical , 2018, 255: 2378-2383.

DOI：10.1016/j.snb.2017.09.042

• Fluorescent probes
• Hypochlorite
• Recognition mechanism
• Aldehyde group
• Bioimaging

In this study, we have developed two fluorescent probes for hypochlorite based on a novel recognition mechanism: aldehyde group oxidized into carboxyl group by sodium hypochlorite. The new mechanism was proved by H-1 NMR, C-13 NMR and ESI-MS analysis for their reacting products. UV-vis and fluorescence titration spectra for ClO- were investigated in PBS (pH 7.4). The detection limits of probe 1 and probe 2 were found to be as low as 77.82 nM and 61.14 nM, respectively. Furthermore, the probes could be used to monitor intracellular ClO- in RAW264.7 macrophage cells.

• 出版日期2018-2
• 单位中国科学院长春应用化学研究所; 山西大学