Comparative study between 2 different doses of pregabalin and lidocaine on pain following propofol injection A double-blind, randomized clinical consort study

作者：Choi Eunkyung; Kim Donggyeong; Jeon Younghoon^*

来源：Medicine, 2016, 95(51): e5153.

DOI：10.1097/MD.0000000000005153

• injection
• lidocaine
• pain
• pregabalin
• propofol

Background: Propofol, an intravenous anesthetic, often causes pain on injection, which can be very distressful to patients. We investigated the analgesic effect of pregabalin on pain following propofol injection, compared with lidocaine.
Methods: In a randomized, double-blind, prospective trial, 120 patients were randomized into 3 groups of 40 each; who received oral placebo and intravenous lidocaine 40mg with venous occlusion for 1 minute (group L, n=40), oral pregabalin 75mg and intravenous normal saline with venous occlusion for 1 minute (group LP, n=40), and oral pregabalin 150 mg and intravenous normal saline with venous occlusion for 1 minute (group HP, n=40) as pretreatment, followed by administration of 1% propofol 0.5mg/kg. Pain intensity was measured on a 4-point scale (0=no, 1=mild, 2=moderate, and 3=severe pain). Any side effects associated with pretreatment substances were recorded during the first 24 hours after surgery.
Results: A total of 120 patients completed this trial. Demographic data were similar between groups. The incidence of pain following propofol injection was significantly reduced in group HP (50%) and group L (55%) compared with group LP (92.5%) (P<0.05, respectively). The incidences of moderate pain in group HP (12.5%) and group L (15%) were significantly decreased compared with group LP (37.5%; both, P<0.05). There were no significant differences in the incidence of side effects such as headache and dizziness between groups.
Conclusion: Pretreatment with oral pregabalin 150 mg and intravenous lidocaine 40mg with venous occlusion equally reduced pain from propofol injection.

• 出版日期2016-12