A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

作者:Lincoln Kimberly M; Gonzalez Paulina; Richardson Timothy E; Julovich David A; Saunders Ryker; Simpkins James W; Green Kayla N*
来源:Chemical communications, 2013, 49(26): 2712-2714.
DOI:10.1039/c2cc36808k

摘要

Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.

  • 出版日期2013