科研之友
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摘要
A full account of the evolution of a convergent total synthesis of gonytolide C is reported. The assembly of the natural product core relies on a Horner-Wadsworth-Emmons (HWE) olefination followed by an intramolecular oxa-Michael addition. Robust and efficient preparations of both HWE coupling partners were established. The synthesis enabled further investigation of an asymmetric oxa-Michael cyclisation to prepare gonytolide C, demonstrating the utility of this strategy for synthesis of 2,2-disubstituted chromanones.
- 出版日期2016-2
