Age at menarche and risk of all-cause and cardiovascular mortality: a systematic review and dose-response meta-analysis

作者：Chen, Xu; Liu, Yu; Sun, Xizhuo; Yin, Zhaoxia; Li, Honghui; Liu, Xuejiao; Zhang, Dongdong; Cheng, Cheng; Liu, Leilei; Liu, Feiyan; Zhou, Qionggui; Wang, Chongjian; Li, Linlin; Wang, Bingyuan; Zhao, Yang; Liu, Dechen; Zhang, Ming; Hu, Dongsheng^*

来源：Menopause-The Journal of the North American Menopause Society, 2019, 26(6): 670-676.

DOI：10.1097/GME.0000000000001289

• Cohort studies
• Menarche
• Meta-analysis
• Mortality

Objective: The evidence between age at menarche and mortality risk is controversial. We aimed to quantify the dose-response association of age at menarche and risk of all-cause and cardiovascular disease (CVD) mortality based on cohort studies. @@@ Methods: PubMed, EMBASE, Web of Science, and Scopus databases were searched up to March 15, 2018 for relevant articles. Random-effects models and restricted cubic splines were used for this meta-analysis. @@@ Results: Twelve cohort studies, with 79,363 deaths and 2,341,769 participants, met the inclusion criteria. With each 1-year increase in menarche age, the relative risk (RR) was reduced for all-cause mortality (RR: 0.977, 95% confidence interval [CI]: 0.970-0.984), CVD mortality (RR: 0.993, 95% CI: 0.975-1.011), ischemic heart disease (IHD) mortality (RR: 0.969, 95% CI: 0.947-0.993), and stroke mortality (RR: 0.983, 95% CI: 0.954-1.012). We found a nonlinear dose-response association (P-nonlinearity = 0.001) between age at menarche and all-cause mortality, with the lowest risk observed at menarche age 15 years (RR: 0.849 95% CI: 0.800-0.901), but no evidence of a nonlinear association between menarche age and CVD mortality (P-nonlinearity = 0.543), IHD mortality (P-nonlinearity = 0.310), or stroke mortality (P-nonlinearity = 0.824). @@@ Conclusions: Age at menarche is inversely associated with all-cause and IHD mortality.

• 出版日期2019-6
• 单位郑州大学; 深圳大学