科研之友
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摘要
We have identified and sequenced a region of the Autographa californica nuclear polyhedrosis virus (AcMNPV) genome encoding the major polyhedron-derived virus structural glycoprotein gp4l. The open reading frame is located entirely within the AcMNPV Sstll-M fragment. The protein sequence does not have hydrophobic regions characteristic of integral membrane proteins and contains a putative 0-linked GlcNAc glycosylation site. gp4l is expressed as a late gene, with transcripts starting within two consensus late transcription start sites (TAAG) located immediately upstream of the first methionine codon. A major transcription termination signal is bypassed, possibly generating a bicistronic message. Finally, the nucleotide and protein sequences of AcMNPV and Bombyx mori nuclear polyhedrosis virus are highly conserved.
- 出版日期1992-8
