Multifractal Spectrum Differentiation of Well-Differentiated Adenocarcinoma from Complex Atypical Hyperplasia of the Uterus

作者：Barwad Adarsh; Dey Pranab^*

来源：Analytical and Quantitative Cytology and Histology, 2012, 34(2): 105-108.

• complex atypical hyperplasia
• endometrial carcinoma
• fractal dimension
• fractal geometry
• multifractal spectrum

OBJECTIVE: To introduce a new field of multifractal spectrum in distinguishing between endometrial well-differentiated adenocarcinoma (WDAC) and complex atypical hyperplasia (CAH).
STUDY DESIGN: Thirteen cases of CAH and 16 of WDAC were selected from radical hysterectomy specimens, and multifractal spectrum was measured from at least 4-5 representative digitized images of each case. The data were collected from f(alpha) vs. alpha curves. The values of alpha max, alpha min, and their difference Delta alpha (alpha max - alpha min) were recorded and the data compared.
RESULTS: The mean +/- SD of alpha max, alpha min, and Delta alpha of CAH were 2.36357 +/- 0.111623, 1.71357 +/- 0.032160, and 0.64214 +/- 0.094248, respectively. The mean +/- SD of alpha max, alpha min, and Delta of WDAC were 2.50640 +/- 0.104545, 1.72100 +/- 0.036436, and 0.77620 +/- 0.108268, respectively. The mean of alpha max, alpha min, and Delta alpha of WDAC were higher than in CAH. Mann-Whitney U test showed significant difference (p <0.0001) of alpha max and Delta alpha of WDAC and CAH.
CONCLUSION: Multifractal dimension is significantly different in WDAC and CAH. The multifractal dimension is a new area in pathology. This study demonstrates the potential usefulness of multifractal analysis in histo pathology. (Anal Quant Cytol Histol 2012;34:105-108)

• 出版日期2012-4
• 单位河北医科大学