Association analysis of PPAR (p.Pro12Ala) polymorphism with type 2 diabetic retinopathy in patients from north India

作者：Kaur Navdeep; Vanita Vanita^*

来源：Ophthalmic Genetics, 2017, 38(3): 217-221.

DOI：10.1080/13816810.2016.1193879

• Case-control association study
• diabetic retinopathy
• PPAR gamma
• p.Pro12Ala polymorphism
• real-time PCR
• T2DM

Background: The present study aimed to examine the association of PPAR (p.Pro12Ala) polymorphism with type 2 diabetic retinopathy (DR) in patients from north India.
Material and methods: In this case-control association study a total of 1325 subjects (717 DR patients and 608 individuals with confirmed type 2 diabetes mellitus (T2DM) without retinopathy taken as controls (CDR)), were recruited. Genotyping for PPAR (p.Pro12Ala) polymorphism was performed by Taqman SNP Genotyping Assays using Real time PCR.
Results: Statistically significant differences were observed between the two analyzed groups in the duration of diabetes and random blood glucose levels (p = 0.000 and p = 0.011, respectively). However, genotype and allele frequency distribution of PPAR (p.Pro12Ala) polymorphism did not differ significantly between DR and CDR groups (p = 0.507 and 0.625, respectively).
Conclusions: These findings suggest no significant association of p.Pro12Ala polymorphism with retinopathy in tested type 2 diabetic retinopathy patients as compared to T2DM individuals take as controls. To our knowledge, this is the first report of association analysis of p.Pro12Ala polymorphism in PPAR in DR patients from India.

• 出版日期2017