The emerging role of E2F-1 in the DNA damage response and checkpoint control

作者：Stevens C; La Thangue NB^*

来源：DNA Repair, 2004, 3(8-9): 1071-1079.

DOI：10.1016/j.dnarep.2004.03.034

• E2F-1
• DNA repair
• DNA damage

Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of DNA repair and apoptosis. A central role for the E2F-1 transcription factor in the DNA damage response pathway is gaining support. E2F-1 is phosphorylated by DNA damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA.

• 出版日期2004-9