Azide-Alkyne Huisgen [3+2] Cycloaddition Using CuO Nanoparticles

作者：Woo Hyunje; Kang Hyuntae; Kim Aram; Jang Seongwan; Park Ji Chan; Park Sungkyun; Kim Byeong Su; Song Hyunjoon; Park Kang Hyun^*

来源：Molecules, 2012, 17(11): 13235-13252.

DOI：10.3390/molecules171113235

• copper oxide
• nanocatalyst
• heterogeneous
• hybrid
• click reaction

Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block copolymer (DHBC) nanoreactors and ZnO-CuO hybrid NPs were synthesized. Non-conventional energy sources such as microwaves and ultrasound were also applied to these click reactions, and good catalytic activity with high regioselectivity was observed. CuO hollow NPs on acetylene black can be recycled nine times without any loss of activity, and water-soluble DHBC nanoreactors have been developed for an environmentally friendly process.

• 出版日期2012-11