An AAA plus ATPase Clamshell Targets Transposition

作者：Tsai Chi Lin; Williams Gareth J; Perry J Jefferson P; Tainer John A^*

来源：Cell, 2015, 162(4): 700-702.

DOI：10.1016/j.cell.2015.07.050

DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.

• 出版日期2015-8-13