Decarboxylative dipropargylation of primary amines with propiolic acids and formaldehyde via metal-free coupling

作者：Jia, Huihui; Feng, Huangdi; Sun, Zhihua^*

来源：Tetrahedron, 2015, 71(18): 2724-2728.

DOI：10.1016/j.tet.2015.03.032

• Dipropargylic amines
• Metal-free
• Decarboxylative coupling
• One pot
• Multicomponent reaction

A metal-free decarboxylative coupling reaction, which produced important and useful dipropargylic amines, was developed under mild conditions. This novel methodology showed abroad range of functional-group compatibility for primary amines and propiolic acids, and gave the corresponding products in up to 97% yields.

• 出版日期2015-5-6
• 单位上海工程技术大学