Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

作者：Bateman Randall J^*; Aisen Paul S; De Strooper Bart; Fox Nick C; Lemere Cynthia A; Ringman John M; Salloway Stephen; Sperling Reisa A; Windisch Manfred; Xiong Chengjie

来源：Alzheimer's Research and Therapy, 2011, 3(1): 1.

DOI：10.1186/alzrt59

Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.

• 出版日期2011