Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan

作者：Shen, Te-Chun; Tsai, Chia-Wen; Chang, Wen-Shin; Wang, Shengyu; Chao, Che-Yi; Hsiao, Chieh-Lun; Chen, Wei-Chun; Hsia, Te-Chun^*; Bau, Da-Tian^*

来源：Scientific Reports, 2017, 7(1): 3199.

DOI：10.1038/s41598-017-03523-0

• SINGLE NUCLEOTIDE POLYMORPHISMS
• CHINESE POPULATION
• COLORECTAL-CANCER
• IL-12B POLYMORPHISMS
• CYTOKINE PRODUCTION
• CERVICAL-CANCER
• RISK
• GENE
• IL12B
• DISEASE

Asthma is an inflammatory disease and interleukin 12 (IL-12) may play a regulatory role in allergen-induced inflammation. The aim of this study was to investigate the association of polymorphisms in IL-12A/ IL-12B with asthma. The asthma group included 198 adult patients and the control group included 453 individuals without asthma that were frequency-matched by gender and age. The distribution of genotypic and allelic frequencies of IL-12A rs568408 demonstrated significant differences between case and control groups. Specifically, the percentages of AA genotype of IL-12A rs568408 was significantly higher among asthmatic patients in Taiwan than healthy controls, compared to GG genotype. No significant difference was observed among the IL-12A rs2243115 and IL-12B rs3212227 genotypes between case and control groups. In addition, the A allele at IL-12A rs568408 was associated with more severe symptoms (P = 0.0085) among asthmatic patients. These results suggest that IL-12A rs568408 may contribute to the etiology and symptoms severity of asthma, indicating its usefulness as a predictive and diagnostic biomarker of asthma.

• 出版日期2017-6-9
• 单位中国医科大学; 西安医学院