Mixed lineage leukemia-septin 5 fusion transcript in de novo adult acute myeloid leukemia with t(11;22)(q23;q11.2): A case report

作者：Gao, Wen; Wang, Tong; Wu, Yin; Liu, Hong Xing; Li, Yan Chen; Chen, Wen Ming^*

来源：Oncology Letters, 2014, 7(6): 1930-1932.

DOI：10.3892/ol.2014.1971

• mixed lineage leukemia
• 11q23
• septin 5
• septin
• acute myeloid leukemia

The current report presents a case of de novo acute myeloid leukemia (AML) in a 32-year-old male. Cytogenetic analysis showed that the karyotype of the bone marrow cells was as follows: 46,XY,t(11;22)(q23;q11.2) [13]/46,X,-Y,+10,t(11;22)(q23;q11.2)[7]/47,XY,+10,t(11;22) (q23;q11.2)[1]/46,XY [1]. Fluorescence in situ hybridization analysis using a mixed lineage leukemia (MLL)-specific probe showed a split in the MLL gene. Reverse transcription polymerase chain reaction (PCR) analysis demonstrated an MLL-septin 5 (SEPT5) fusion transcript in the patient. Nucleotide sequencing analysis of the PCR product confirmed the fusion between the MLL exon 9 and SEPT5 exon 3, and the product was 521 bp in length. The present study reviewed the clinical and molecular features of the AML with an MLL-SEPT5 fusion gene.

• 出版日期2014-6
• 单位首都医科大学