A follow-up study on features of sensory gating P50 in treatment-resistant depression patients

作者：Wang Yong; Fang Yi-ru^*; Chen Xing-shi; Chen Jun; Wu Zhi-guo; Yuan Cheng-mei; Yi Zheng-hui; Hong Wu; Zhang Chen; Cao Lan

来源：Chinese Medical Journal, 2009, 122(24): 2956-2960.

DOI：10.3760/cma.j.issn.0366-6999-2009.24.007

• treatment-resistant depression
• sensory gating
• evoked potentials, auditory
• biological markers

Background Depressive disorder is a well-known chronic, recurrent and disabling mental disease with high direct and indirect costs to society in both western and eastern cultures. Approximately 40% of depressed patients show only partial or no response to initial or even multiple antidepressant medications and are usually called treatment-resistant depression (TRD) patients. The present work was to measure the features of sensory gating (SG) P50 in TRD patients with the intent of understanding the characteristics of this disease. @@@ Methods In 50 TRD patients, 39 non-treatment-resistant depression (NTRD) patients and 51 healthy controls (HC), auditory evoked potential P50 was measured using the conditioning/testing paradigm presented with auditory double clicks stimuli, and 36 TRD patients had repeated measurements after an 8-week venlafaxine treatment course. @@@ Results All the depressive disorder patients, including the TRD and NTRD groups, showed an increased testing stimulus wave (S2-P50) amplitude compared to controls (P<0.01 and P<0.05), but there was no significant difference between the TRD and NTRD groups (P>0.05). There were significant differences in the ratio of testing stimulus (S2) and conditioning stimulus (S1) (S2/S1) and in the value of 100 x (1-S2/S1) among the three groups. Compared to the baseline, TRD patients had no significant changes of features and different expression of P50 after acute treatment (P>0.05). Meanwhile, a statistically significant positive correlation of S2/S1 with the scores of the 17-item Hamilton Rating Scale for Depression (HAMD-17) (P<0.01), and a significantly negative correlation of S1-S2, 100 x (1-S2/S1) with the scores of HAMD-17 (P<0.01) were observed in the TRD patients' baseline measurement, but there was no correlation after venlafaxine treatment (P>0.05). @@@ Conclusions Both the TRD and NTRD patients had obvious SG deficits, with a more severe deficit in TRD patients. Although, with a correlated relationship to the severity of depressive symptoms, SG P50 deficit might be suggested as a trait marker for TRD, and a combination of S2/S1 ratio, S1-S2 and 100 x (1-S2/S1), was recommended for electrophysiological measurement in TRD patients.

• 出版日期2009-12-20
• 单位上海市精神卫生中心; 上海交通大学