Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains

作者：Timmermans Steven; Van Montagu Marc^*; Libert Claude^*

来源：Proceedings of the National Academy of Sciences, 2017, 114(34): 9158-9163.

DOI：10.1073/pnas.1706168114

• mouse
• genetics
• sequence
• polymorphisms
• inbred strains

Mouse inbred strains remain essential in science. We have analyzed the publicly available genome sequences of 36 popular inbred strains and provide lists for each strain of protein-coding genes that acquired sequence variations that cause premature STOP codons, loss of STOP codons and single nucleotide polymorphisms, and short in-frame insertions and deletions. Our data give an overview of predicted defective proteins, including predicted impact scores, of all these strains compared with the reference mouse genome of C57BL/6J. These data can also be retrieved via a searchable website (mousepost.be) and allow a global, better interpretation of genetic background effects and a source of naturally defective alleles in these 36 sequenced classical and high-priority mouse inbred strains.

• 出版日期2017-8-22