Association between the serum level of vitamin D and systemic sclerosis in a Chinese population: a case control study

作者：Zhang, Li; Duan, Yu; Zhang, Tian-Ping; Huang, Xiao-Lei; Li, Bao-Zhu; Ye, Dong-Qing; Wang, Jing^*

来源：International Journal of Rheumatic Diseases, 2017, 20(8): 1002-1008.

DOI：10.1111/1756-185X.12794

• fibrosis
• pulmonary involvement
• systemic sclerosis
• vitamin D

AimSeveral autoimmune diseases have been associated with reduced vitamin D levels. However, the serum level of vitamin D in Chinese systemic sclerosis (SSc) patients have not been reported. The aim of this study was to evaluate the serum levels of vitamin D in Chinese SSc patients and analyze the association between vitamin D and SSc.
Methods25-hydroxy vitamin D I-125 RIA kit was applied to evaluate the serum levels of vitamin D in 60 SSc patients and 60 healthy controls from Anhui Provincial Hospital, China. The data of epidemiological and clinical characteristics of SSc patients were also collected.
ResultsThe serum levels of vitamin D were significantly lower in SSc patients than that in healthy controls (26.51 6.27 vs. 36.29 +/- 14.24 ng/mL, P < 0.001). The ratio of pulmonary involvement in vitamin D insufficiency patients was higher than that in normal vitamin D patients, but the difference missed statistical significance. The differences in other aspects were not statistically significant in the two groups.
ConclusionSerum levels of vitamin D in patients with SSc were lower than that in healthy controls. Further studies are needed to determine whether vitamin D supplement could provide some positive effects.

• 出版日期2017-8
• 单位安徽医科大学