Asymmetric Synthesis of Concentricolide

作者：Liu Xiaojing; Hu Lingling; Jiang Lizhen; Jia Junhao; Zhang Di; Chen Xiaochuan^*

来源：European Journal of Organic Chemistry, 2015, 2015(10): 2291-2296.

DOI：10.1002/ejoc.201403604

• Natural products
• Asymmetric synthesis
• Chiral auxiliaries
• Phthalides
• Medicinal chemistry

A practical strategy for the synthesis of both (-)- and (+)-concentricolide from salicylic acid has been developed. The key feature of the approach is sequential aromatic lithiation and condensation with an aldehyde directed by a chiral oxazoline unit derived either from L- or D-phenylalaninol, which is employed as an auxiliary.

• 出版日期2015-4
• 单位四川大学