科研之友
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摘要
A glycosylated tetrahydroxanthone mimicking the ABC subunit of kigamicin A is synthesised in five steps by a sequence that exploits a Pd catalysed C-O bond forming reaction to construct the tetrahydroxanthone nucleus; chemo- and enantioselective Ru-catalysed transfer hydrogenation to establish the C-14 hydroxyl stereochemistry in the A-ring; and a trichloroacetimidate activated donor to introduce the beta-linked D-amicetose unit in a stereoselective manner.
- 出版日期2013-11-27
