An efficient route to quinoline-2-carboxylates via a rhodium-catalyzed oxidative [5+1] annulation of 2-vinylanilines with alpha-diazocarbonyl compounds

作者：Wang, Cong; Ding, Qiuping^*; Zheng, Qiang; Bao, Ping; Peng, Yiyuan

来源：Tetrahedron, 2018, 74(2): 348-353.

DOI：10.1016/j.tet.2017.12.004

• 2-Vinylaniline
• alpha-Diazocarbonyl
• [5+1] annulation

A novel rhodium-catalyzed oxidative [5 +1]annulation of 2-vinylanilines with alpha-diazocarbonyl compounds for the construction of quinoline-2-carboxylate derivatives has been developed. A series of functional groups such as methyl, methoxy, fluoro, chloro, bromo, cyano, and even thienyl substituents were tolerated well. This methodology has the potential for use in the pharmaceutical industry.

• 出版日期2018-1-11
• 单位江西师范大学