A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicium var. thyrsiflorum

作者：Abdelhady Mohamed I S^*; Motaal Amira Abdel

来源：Brazilian Journal of Pharmacognosy, 2016, 26(6): 763-766.

DOI：10.1016/j.bjp.2016.06.004

• Ocimum basilicium
• HCT116
• Cytotoxic
• Antioxidant
• C-glycosylation
• Apigenin derivative

The standardized 80% ethanolic extract of the leaves of Ocimum basilicum var. thyrsiflorum (L.) Benth., Lamiaceae, growing in KSA, exhibited a significant antioxidant activity compared to the ethyl acetate and butanol extracts, which was correlated to its higher phenolic and flavonoid contents. Chromatographic separation of the 80% ethanol extract resulted in the isolation of ten known compounds; cinnamic acid, gallic acid, methylgallate, ellagic acid, methyl ellagic acid, apigenin, luteolin, vitexin, isovitexin, and 3 ''-O-acetylvitexin. Compound 3 ''-O-acetylvitexin, a C-glycosylated derivative of apigenin, was isolated for the first time from genus Ocimum. The 80% ethanolic extract and 3 ''-O-acetylvitexin showed significant cytotoxic activities against the HCT116 human colon cancer cell line [IC50 values 22.3 +/- 1.1 and 16.8 +/- 2.0 mu g/ml (35.4 mu M), respectively].

• 出版日期2016-12