Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa

作者：Ebada Sherif S^*; Linh Mai Hoang; Longeon Arlette; de Voogd Nicole J; Durieu Emilie; Meijer Laurent; Bourguet Kondracki Marie Lise; Singab Abdel Nasser B; Mueller Werner E G; Proksch Peter

来源：Natural Product Research, 2015, 29(3): 231-238.

DOI：10.1080/14786419.2014.947496

• bromopyrrole alkaloids
• antiproliferative
• protein kinase
• neurodegenerative disorders

Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.

• 出版日期2015-2-1