Sources of Parent-Child Transmission of Drug Abuse Path Analyses of Not-Lived-With Parental, Stepparental, Triparental, and Adoptive Families

作者：Kendler Kenneth S.; Ohlsson Henrik; Sundquist Kristina; Sundquist Jan

来源：Journal of Nervous and Mental Disease, 2018, 206(4): 239-244.

DOI：10.1097/NMD.0000000000000775

• Drug abuse
• Sweden
• genetics
• parent-offspring
• rearing
• environment

To clarify the origins of parent-child resemblance for drug abuse (DA), using national Swedish data, we fit path models to information on DA in parents and children from six informative family types: i) not-lived-with father, ii) not-lived-with mother, iii) stepfather, iv) stepmother, v) triparental, and vi) adoptive. From these families, we estimated parent-offspring resemblance reflecting the effects of genes + rearing, genes only, and rearing only. The estimates of parent-offspring correlations were statistically homogenous across family types. The weighted estimate of the father-offspring correlation for DA for genes + rearing, genes-only, and rearing-only relationships were, respectively, +0.26, +0.19, and +0.06. Parallel figures for mother-offspring relationships were +0.19, +0.13, and +0.09. In both genes + rearing and genes-only parent-offspring relationships, DA correlations were stronger for fathers than for mothers. Both genetic and environmental factors contribute substantially to parent-offspring resemblance for DA and seem to be additive.

• 出版日期2018-4