Accuracy of micro powder dosing via a vibratory sieve-chute system

作者：Besenhard M O; Faulhammer E; Fathollahi S; Reif G; Calzolari V; Biserni S; Ferrari A; Lawrence S M; Llusa M; Khinast J G^*

来源：European Journal of Pharmaceutics and Biopharmaceutics, 2015, 94: 264-272.

DOI：10.1016/j.ejpb.2015.04.037

• Micro dosing
• Micro feeding
• Capsule filling
• Vibratory sieve
• Online scale
• Lactose

This paper describes a powder dosing system with a vibratory sieve mounted on a chute that doses particles into a capsule. Vertical vibration occurred with a broad range of frequencies and amplitudes. During dosing events, the fill weight was accurately recorded via a capacitance sensor, covering the capsules and making it possible to analyze filling characteristics, that is, the fill rates and their robustness. The range of frequencies and amplitudes was screened for settings that facilitated reasonable (no blocking, no spilling) fill rates for three lactose powders. The filling characteristics were studied within this operating space. The results reveal similar operating spaces for all investigated powders. The fill rate robustness varied distinctly in the operating space, which is of prime importance for selecting the settings for continuous feeding applications. In addition, we present accurate dosing studies utilizing the knowledge about the filling characteristics of each powder.

• 出版日期2015-8