Distribution of 28 kDa Calbindin-Immunopositive Neurons in the Cat Spinal Cord

作者：Merkulyeva Natalia; Veshchitskiii Aleksandr; Makarovi Felix; Gerasimenko Yury; Musienko Pavel^*

来源：Frontiers in Neuroanatomy, 2016, 9: 166.

DOI：10.3380/fnana.2015.00166

• spinal cord
• gray matter
• interneurons
• Ca2+-binding proteins
• calbindin-28 kDa

The distribution of vitamin D-dependent calcium-binding protein (28 kDa calbindin) was investigated in cat lumbar and sacral spinal cord segments (L1-S3). We observed specific multi-dimensional distributions over the spinal segments for small immunopositive cells in Rexed laminae II-III and medium-to-large cells of varying morphology in lamina I and laminae V-VIII. The small neurons in laminae II-III were clustered into the columns along the dorsal horn curvature. The medium-to large cells were grouped into four assemblages that were located in (1) the most lateral region of lamina VII at the L1-L4 level; (2) the laminae IV-V boundary at the L5-L7 level; (3) the lamina VII dorsal border at the L5-L7 level; and (4) the lamina VIII at the L5-S3 level. The data obtained suggest that the morphological and physiological heterogeneity of calbindin immunolabeling cells formed morphofunctional clusters over the gray matter. A significant portion of the lumbosacral enlargement had immunopositive neurons within all Rexed laminae, suggesting an important functional role within and among the spinal networks that control hindlimb movements.

• 出版日期2016-1-28