Secovironolide, a novel furanosteroid scaffold with a five-membered B ring from the endophytic fungus Talaromyces wortmannii LGT-4

作者：Ding, Hai-E.; Yang, Zhong-Duo^*; Sheng, Li; Zhou, Shuang-Yan; Li, Shuo; Yao, Xiao-Jun; Zhi, Kang-Kang; Wang, Yong-Gang; Zhang, Fei

来源：Tetrahedron Letters, 2015, 56(48): 6754-6757.

DOI：10.1016/j.tetlet.2015.10.063

• Secovironolide
• Furanosteroid
• Talaromyces wortmannii
• Epoxyvirone

Secovironolide (1) was purified from the culture broth of Talaromyces wortmanni and is the first example of a furanosteroid scaffold bearing a five-membered B ring. The structure of 1 was elucidated by comprehensive NMR spectroscopy and single-crystal X-ray crystallography. Additional known viridian derivatives (2-5, 7) were isolated, including the new epoxide containing compound, epoxyvirone (6). Isolates were tested for monoamine oxidase (MAO) inhibitory activity and showed only weak activity.

• 出版日期2015-12-2
• 单位兰州理工大学; 兰州大学